Conformational Analysis of Benzyloxycarbonyl-Protected Peptides
نویسنده
چکیده
The benzyloxycarbonyl (Z-) residue, an important protecting group in peptide synthesis, was introduced into the input data set o f the “Empirical Conformational Energy Program for Peptides” (ECEPP) developed by Scheraga and coworkers. With additional modifications ECEPP is now prepared for conformational analysis o f peptides containing this amino end group. Preferred conformations o f the Z-residue were studied by performing calculations on Z-Gly methylamide. The results obtained may be applied to the conformational analysis o f Z-protected peptides.
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تاریخ انتشار 2013